Autonomous Breakdown of the Allergen Tolerance in the Nose: A Hypothesis

The prevalence of conventional and new pathogenic types allergies is increasing. For the last few years, atopic disorders – local allergic rhinitis (LAR), asthma, “dual” rhinitis, conjunctivitis have been described. In particular, LAR was identified a decade ago, whereas its immunopathogenesis still unclear. Nevertheless, network immune cells neurons determining maintenance or breakdown allergen tolerance has partially studied. Therefore, this field research currently at cutting edge. However, there not any definitive answer as to why take place. Specifically, nasal cavity characterized by following prevalent neuro molecules: acetylcholine, norepinephrine, substance P, neuromedin U, vasoactive intestinal peptide, calcitonin-gene-related peptide; some which are pro-immunogenic slightly smaller part protolerogenic. spotlight, hypothesis an autonomous allergens in presented. article describes antipode active response, does lead producing effector molecules, vice versa based on immunosuppressive processes. addition, focuses mechanisms tolerance, form level throughout body, essential role various including pathogenesis LAR.